ONO 2506

Cat. No. 4530

ONO 2506 C11H22O2 [185517-21-9]

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Alternative Name: Arundic acid

Chemical Name: (2R)-2-Propyloctanoic acid

Biological Activity

Inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.

Technical Data

M.Wt:
186.29
Formula:
C11H22O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
185517-21-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Tateishi et al (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits. J.Cereb.Blood Flow Metab. 22 723. PMID: 12045671.

Kato et al (2004) Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice. Brain Res. 1030 66. PMID: 15567338.

Mori et al (2006) Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 318 571. PMID: 16709678.

If you know of a relevant citation for this product please let us know.

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Keywords: ONO 2506, supplier, ONO2506, S100B, bbb, blood, brain, barrier, stroke, neuroprotective, Alzheimer's, parkinson's, disease, astrocytes, astrocytic, arundic, acid, parkinsons, alzheimers, Tocris Bioscience, Neuronal Metabolism

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