R&D Systems Inc. Tocris Bioscience Boston Biochem

ONO 2506

Cat. No. 4530

ONO 2506 C11H22O2 [185517-21-9]

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Alternative Name: Arundic acid

Chemical Name: (2R)-2-Propyloctanoic acid

Biological Activity

Inhibits S100B synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.

Technical Data

M.Wt:
186.29
Formula:
C11H22O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
185517-21-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Tateishi et al (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits. J.Cereb.Blood Flow Metab. 22 723. PMID: 12045671.

Kato et al (2004) Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice. Brain Res. 1030 66. PMID: 15567338.

Mori et al (2006) Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 318 571. PMID: 16709678.

If you know of a relevant citation for this product please let us know.

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Keywords: ONO 2506, supplier, ONO2506, S100B, bbb, blood, brain, barrier, stroke, neuroprotective, Alzheimer's, parkinson's, disease, astrocytes, astrocytic, arundic, acid, parkinsons, alzheimers

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