Cat. No. 4529
Alternative Name: HPI-4
Chemical Name: 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
Biological ActivityHedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Peturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 106 14132. PMID: 19666565.
Firestone et al (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484 7392. PMID: 22425997.
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Keywords: Ciliobrevin A, supplier, CiliobrevinA, supplier, hedgehog, Hh, pathway, antagonists, blocks, inhibits, inhibitors, Smo, smoothened, patched, ciliogenesis, cilia, microtubules, dynein, cytoplasmic, AAA+, ATPase, HPI-4
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