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Cytarabine

Cat. No. 4520

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Alternative Name: Cytosine b-D-arabinofuranoside

Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

Biological Activity

Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC₅₀ = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data

M.Wt:

243.22

Formula:

C₉H₁₃N₃O₅

Solubility:

Soluble to 100 mM in water and to 50 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

147-94-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Yang et al (1986) Effect of cytarabine upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368. PMID: 2954403.

Breistøl et al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944. PMID: 10383159.

Sampath et al (2006) Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517. PMID: 16293603.

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