R&D Systems Inc. Tocris Bioscience Boston Biochem

2-Deoxy-D-glucose

Cat. No. 4515

2-Deoxy-D-glucose C6H12O5 [154-17-6]

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Chemical Name: 2-Deoxy-D-arabino-hexose

Biological Activity

Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).

Technical Data

M.Wt:
164.16
Formula:
C6H12O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at +4°C
CAS No:
154-17-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Maher et al (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 53 116. PMID: 14605866.

Kang and Hwang (2006) 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78 1392. PMID: 16111712.

Ralser et al (2008) A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 105 17807.

If you know of a relevant citation for this product please let us know.

Keywords: 2-Deoxy-D-glucose, supplier, non-metabolizable, hexokinase, substrates, hypoxia, hypoxic, cell, growth, inhibitors, inhibition

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