2-Deoxy-D-glucose

Cat. No. 4515

2-Deoxy-D-glucose C6H12O5 [154-17-6]

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Chemical Name: 2-Deoxy-D-arabino-hexose

Biological Activity

Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).

Technical Data

M.Wt:
164.16
Formula:
C6H12O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at +4°C
CAS No:
154-17-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Maher et al (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 53 116. PMID: 14605866.

Kang and Hwang (2006) 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78 1392. PMID: 16111712.

Ralser et al (2008) A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 105 17807.

If you know of a relevant citation for this product please let us know.

Keywords: 2-Deoxy-D-glucose, supplier, non-metabolizable, hexokinase, substrates, hypoxia, hypoxic, cell, growth, inhibitors, inhibition

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