Cat. No. 4515
Chemical Name: 2-Deoxy-D-arabino-hexose
Biological ActivityNon-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Maher et al (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 53 116. PMID: 14605866.
Kang and Hwang (2006) 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78 1392. PMID: 16111712.
Ralser et al (2008) A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 105 17807.
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Keywords: 2-Deoxy-D-glucose, supplier, non-metabolizable, hexokinase, substrates, hypoxia, hypoxic, cell, growth, inhibitors, inhibition
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