Cat. No. 4511
Alternative Name: mono-Methyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Biological ActivityNuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207. PMID: 9613834.
Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562. PMID: 18722346.
Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910. PMID: 20664170.
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274. PMID: 22267202.
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Keywords: MMF, supplier, monomethylfumarate, nuclear, factor, erythroid, derived, like, 2, pathway, Nrf2, activators, GPR109A, niacin, nicotinic, acid, receptors, agonists, metabolite, dimethylfumarate, DMF
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