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MMFCat. No. 4511 |
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Alternative Name: mono-Methyl fumarate Chemical Name: 2(E)-Butenedioic acid 1-methyl ester |
Biological Activity
Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).Certificate of Analysis / Safety Data Sheet
References
Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207. PMID: 9613834.
Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562. PMID: 18722346.
Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910. PMID: 20664170.
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274. PMID: 22267202.
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Keywords: MMF, supplier, monomethylfumarate, nuclear, factor, erythroid, derived, like, 2, pathway, Nrf2, activators, GPR109A, niacin, nicotinic, acid, receptors, agonists, metabolite, dimethylfumarate, DMF
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