R&D Systems Inc. Tocris Bioscience Boston Biochem

17-AAG

Cat. No. 1515

17-AAG C31H43N3O8 [75747-14-7]

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Alternative Names: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin

Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin

Biological Activity

Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Technical Data

M.Wt:
585.7
Formula:
C31H43N3O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
75747-14-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Schnur et al (1995) Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J.Med.Chem. 38 3806. PMID: 7562911.

Hostein et al (2001) Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 61 4003. PMID: 11358818.

Yang et al (2001) Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 61 4010. PMID: 11358819.

Wang et al (2011) Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. J.Neurochem. 117 703. PMID: 21395580.

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Keywords: 17-AAG, supplier, Selective, Hsp90, inhibitors, Heat, Shock, Protein, 90, NSC330507, antibiotics, stem, cells, protects, neural, progenitors, neuorprogenitors, stress-induced, apoptosis

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