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17-AAGCat. No. 1515 |
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Alternative Names: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin |
Biological Activity
Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo.Certificate of Analysis / Safety Data Sheet
References
Schnur et al (1995) Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J.Med.Chem. 38 3806. PMID: 7562911.
Hostein et al (2001) Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 61 4003. PMID: 11358818.
Yang et al (2001) Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 61 4010. PMID: 11358819.
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Keywords: 17-AAG, supplier, Selective, Hsp90, inhibitors, Heat, Shock, Protein, 90, NSC330507, antibiotics
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