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STF 083010Cat. No. 4509 |
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Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide |
Biological Activity
Inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.Certificate of Analysis / Safety Data Sheet
Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet
References
Papandreou et al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311. PMID: 21081713.
Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53. PMID: 22112465.
If you know of a relevant citation for this product please let us know.
Keywords: STF 083010, supplier, STF083010, IRE1alpha, IRE1a, IRE1α, inhibitors, endonucleases, RNases, XBP, mRNA, splicing, inositol, requiring, enzyme, endoplasmic, reticulum
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