Cat. No. 4495
Alternative Name: (R)-Flurbiprofen
Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
Biological ActivityNonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Eriksen et al (2003) NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440. PMID: 12897211.
Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54. PMID: 17650315.
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Keywords: Flurizan, supplier, NSAIDs, gamma, secretase, inhibitors, AB42, beta, amyloid, flurbiprofen, tarenflurbil, R-flurbiprofen, Aβ42, and, Abeta42
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October 15, 2013