Cat. No. 4490
Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
Biological ActivitySesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Dupuis & Brisson et al (1976) Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 15 205. PMID: 1000726.
Pal et al (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 24 1599. PMID: 20600805.
Shi et al (2011) Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway. J.Biomol.Screen. 16 525. PMID: 21378277.
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Keywords: Alantolactone, supplier, antiproliferative, sesquiterpene, lactones, activin, SMAD3, type, II, A, receptors
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