Signal Transduction
Stem Cells
Signaling Pathways
Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
AlantolactoneCat. No. 4490 |
Price and AvailabilityBy clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy. |
|
Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one |
Biological Activity
Sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.Certificate of Analysis / Safety Data Sheet
References
Dupuis & Brisson et al (1976) Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 15 205. PMID: 1000726.
Pal et al (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 24 1599. PMID: 20600805.
Shi et al (2011) Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway. J.Biomol.Screen. 16 525. PMID: 21378277.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Alantolactone, supplier, antiproliferative, sesquiterpene, lactones, activin, SMAD3, type, II, A, receptors
Quick Order
Find multiple products by catalog number
Cancer Research Guide
Request your free copy
Highlights over 350 products for cancer research. Request a copy or view PDF today.
Kinases Product Listing
Highlights over 350 products for kinase research. Request a copy or view PDF today.
Kinase Inhibitor Toolbox
80 Kinase inhibitors
pre-dissolved in DMSO
Some of the most potent
kinase inhibitors all on one plate
Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.
TGF-β Pathway
TGF-β signaling is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis. View pathway or download PDF today.
Tocris Events
Win a Kindle
Federation of European Biochemical Societies Congress 2013
July 6 - 11, 2013
St. Petersburg, Russia
Booth Number: 128