Home » Pharmacology » Enzymes » Proteases » Other Proteases » PMSF

PMSF

Cat. No. 4486

Price and Availability

For PMSF pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: Phenylmethylsulfonyl fluoride

Biological Activity

Non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t_1/2 ~ 60 mins at pH 7.5). Brain penetrant.

Technical Data

M.Wt:

174.19

Formula:

C₇H₇FO₂S

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

329-98-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Turini et al (1969) The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotrypsin and trypsin. J.Pharmacol.Exp.Ther. 167 98. PMID: 4306345.

Compton & Martin (1997) The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J.Pharmacol.Exp.Ther. 283 1138. PMID: 9399986.

Day et al (2001) Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. Mol.Pharmacol. 59 1369. PMID: 11353795.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Other Proteases

Proteases

Keywords: PMSF, supplier, proteases, inhibits, inhibitors, irreversible, sulfonation, brain, penetrant, FAAH, anandamide, fatty, acid, amide, hydrolase