R&D Systems Inc. Tocris Bioscience Boston Biochem

A 484954

Cat. No. 4483

A 484954 C13H15N5O3 [142557-61-7]

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Chemical Name: 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide

Biological Activity

Inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.

Technical Data

M.Wt:
289.29
Formula:
C13H15N5O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
142557-61-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Chen et al (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951. PMID: 22020937.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: A 484954, supplier, A484954, eukaryotic, elongation, factor-2, kinase, eef2k, inhibitors

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