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Ki 20227

Cat. No. 4481

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Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea

Biological Activity

Inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC₅₀ values are 2, 12, 451 and 217 nM for c-Fms, VEGFR-2, c-Kit and PDGFRβ respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses ostolysis and osteoclast accumulation induced by metastatic tumor cells.

Technical Data

M.Wt:

480.54

Formula:

C₂₄H₂₄N₄O₅S

Solubility:

Soluble to 100 mM in DMSO

Purity:

>97 %

Storage:

Store at +4°C

CAS No:

623142-96-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Ohno et al (2006) A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol.Cancer Ther. 5 2634. PMID: 17121910.

Ohno et al (2007) The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur.J.Immunol. 38 283. PMID: 18085662.

Kubota et al (2009) M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J.Exp.Med. 206 1089. PMID: 19398755.

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Keywords: Ki 20227, supplier, Ki20227, c-Fms, macrophage, colony-stimulating, factor, receptors, M-CSFR, CSF1R, inhibitors, inhibits, osteolysis, osteoclast