R&D Systems Inc. Tocris Bioscience Boston Biochem

4μ8C

Cat. No. 4479

4mu8C C11H8O4 [14003-96-4]

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Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzo­pyran-8-carboxaldehyde

Biological Activity

Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Technical Data

M.Wt:
204.18
Formula:
C11H8O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
14003-96-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869. PMID: 22315414.

If you know of a relevant citation for this product please let us know.

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Esterases
IRE1

Keywords: 4mu8C, supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, ire1, rnase, endoribonuclease

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