Cat. No. 4479
Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Biological ActivitySelective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869. PMID: 22315414.
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Keywords: 4mu8C, supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, ire1, rnase, endoribonuclease
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