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DMH4Cat. No. 4471 |
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Chemical Name: 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyrimidine |
Biological Activity
Selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Displays antiangiogenic activity in vitro and in vivo.Certificate of Analysis / Safety Data Sheet
References
Fraley et al (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg.Med.Chem.Lett. 12 3537. PMID: 12443771.
Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245. PMID: 20020776.
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Keywords: DMH4, supplier, VEGFR-2, inhibitors, dorsomorphin, vascular, endothelial, growth, factor, receptor-2, KDR
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