R&D Systems Inc. Tocris Bioscience Boston Biochem

PHP 501 trifluoroacetate

Cat. No. 4466

PHP 501 trifluoroacetate C20H21N3O.CF3CO2H [1236105-75-1]

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Chemical Name: 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-1H-pyrazol-4-yl)piperidine trifluoroacetate

Biological Activity

Potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.

Technical Data

M.Wt:
433.42
Formula:
C20H21N3O.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1236105-75-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417. PMID: 20355712.

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Keywords: PHP 501 trifluoroacetate, supplier, GABAA, receptors, antagonists, potent, PHP501

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