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PHP 501 trifluoroacetate

Cat. No. 4466

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Chemical Name: 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-1H-pyrazol-4-yl)piperidine trifluoroacetate

Biological Activity

Potent GABA_A antagonist (K_i = 0.0028 μM at rat GABA_A receptors; IC₅₀ = 0.024 μM at human α₁β₂γ₂ GABA_A-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.

Technical Data

M.Wt:

433.42

Formula:

C₂₀H₂₁N_3O.CF₃CO₂H

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

1236105-75-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417. PMID: 20355712.

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