PHP 501 trifluoroacetate
Cat. No. 4466
Chemical Name: 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-
Biological ActivityPotent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417. PMID: 20355712.
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Keywords: PHP 501 trifluoroacetate, supplier, GABAA, receptors, antagonists, potent, PHP501
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