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IOX 2Cat. No. 4451 |
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Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine |
Biological Activity
Potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.Structural Genomics Consortium (SGC) Collaboration
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.Certificate of Analysis / Safety Data Sheet
Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet
References
Murray et al (2010) Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 12 676. PMID: 20666436.
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Keywords: IOX 2, supplier, supplier, IOX2, hypoxia, inducible, factor, 1, alpha, 1a, HIF1a, HIF1alpha, prolyl, hydroxylases, potent, inhibits, inhibitor, selective, cell, permeable, epigenetics, probe, JICL38
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