Cat. No. 4451
Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(
Biological ActivityPotent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Murray et al (2010) Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 12 676. PMID: 20666436.
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Keywords: IOX 2, supplier, supplier, IOX2, hypoxia, inducible, factor, 1, alpha, 1a, HIF1a, HIF1alpha, prolyl, hydroxylases, potent, inhibits, inhibitor, selective, cell, permeable, epigenetics, probe, JICL38