R&D Systems Inc. Tocris Bioscience Boston Biochem

IOX 2

Cat. No. 4451

IOX 2 C19H16N2O5 [931398-72-0]

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Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine

Biological Activity

Potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.

Technical Data

M.Wt:
352.34
Formula:
C19H16N2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
931398-72-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Murray et al (2010) Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 12 676. PMID: 20666436.

If you know of a relevant citation for this product please let us know.

Keywords: IOX 2, supplier, supplier, IOX2, hypoxia, inducible, factor, 1, alpha, 1a, HIF1a, HIF1alpha, prolyl, hydroxylases, potent, inhibits, inhibitor, selective, cell, permeable, epigenetics, probe, JICL38

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