Cat. No. 4446
Chemical Name: 2-[Methyl(tetrahydro-1,1-dioxido-3-
Biological ActivityInhibitor of Krüppel-like factor 5 (KLF5) transcription factor (IC50 = 2.3 μM). Selectively active against colon cancer cells in a panel of 60 different cancer cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bialkowska et al (2011) Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol.Cancer Ther. 10 2043. PMID: 21885866.
If you know of a relevant citation for this product please let us know.
Keywords: CID 5951923, supplier, CID5951923, krueppel, kruppel, krüppel-like, factors, klf5, inhibitors, inhibits
Find multiple products by catalog number
New Products in this Area
High affinity Myc inhibitorEchinomycin
Highly potent and selective HIF-1α inhibitorNK 252
Nrf2 activatorCDDO Im
Nrf2 signaling activatorVerteporfin
YAP inhibitor; disrupts YAP-TEAD interactionsTC-S 7009
High affinity and selective HIF-2α inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.