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Fatostatin A

Cat. No. 4444

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Chemical Name: 4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide

Biological Activity

Inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC₅₀ = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.

Technical Data

M.Wt:

375.33

Formula:

C₁₈H₁₈N₂S.HBr

Solubility:

Soluble to 20 mM in DMSO

Purity:

>97 %

Storage:

Store at +4°C

CAS No:

298197-04-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Choi et al (2003) Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 278 7320. PMID: 12496288.

Kamisuki et al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 16 882. PMID: 19716478.

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Keywords: Fatostatin A, supplier, sterol, regulatory, element, binding, proteins, SREBPs, SREBP1, SREBP2, inhibition, inhibitors, antiproliferatives, 125B11, FatostatinA