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SEN 12333

Cat. No. 4441

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Alternative Name: WAY 317538

Chemical Name: N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide

Biological Activity

α7 nicotinic acetylcholine receptor (nAChR) agonist (EC₅₀ = 1.6 μM, K_i = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H₃ receptors (IC₅₀ = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC₅₀ = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.

Technical Data

M.Wt:

339.43

Formula:

C₂₀H₂₅N₃O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

874450-44-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Roncarati et al (2009) Procognitive and neuroprotective activity of a novel α7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J.Pharmacol.Exp.Ther. 329 459. PMID: 19223665.

Beinat et al (2012) Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg.Med.Chem.Lett. 22 2380. PMID: 22410083.

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