Cat. No. 4441
Alternative Name: WAY 317538
Chemical Name: N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide
Biological Activityα7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Roncarati et al (2009) Procognitive and neuroprotective activity of a novel α7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J.Pharmacol.Exp.Ther. 329 459. PMID: 19223665.
Beinat et al (2012) Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg.Med.Chem.Lett. 22 2380. PMID: 22410083.
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Keywords: SEN 12333, supplier, SEN12333, WAY317538, WAY, 317538, alpha7, a7, α7, nicotinic, acetylcholine, receptors, nAChR, agonists, histamine, h3, receptors, functional, antagonists, brain, penetrant, orally, bioavailable
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