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TC-N 1752

Cat. No. 4435

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Chemical Name: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide

Biological Activity

Selective blocker of human Na_V1.7 channels (IC₅₀ values are 0.17, 0.3, 0.4 and 1.1 μM at hNa_V1.7, hNa_V1.3, hNa_V1.4 and hNa_V1.5 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

Technical Data

M.Wt:

516.52

Formula:

C₂₅H₂₇F₃N₆O₃

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

1211866-85-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Bregman et al (2011) Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 54 4427. PMID: 21634377.

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Keywords: TC-N 1752, supplier, TCN1752, sodium, channels, blockers, selective, nav1.7, analgesics

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