R&D Systems Inc. Tocris Bioscience Boston Biochem

BAY 41-2272

Cat. No. 4430

BAY 41-2272 C20H17FN6 [256376-24-6]

Price and Availability

For BAY 41-2272 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-Cyclopropyl-2-[1-[(2-fluorophenyl­)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimid­inamine

Biological Activity

Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Technical Data

M.Wt:
360.39
Formula:
C20H17FN6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
256376-24-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Mittendorf et al (2009) Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4 853. PMID: 19263460.

Stasch et al (2010) NO-independent regulatory site on soluble guanylate cyclase. Nature 410 212. PMID: 11242081.

Joshi et al (2011) The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 339 394. PMID: 21825001.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Cyclases Enzyme Substrates / Activators Guanylyl Cyclase
Nitric Oxide Signaling Other Nitric Oxide

Keywords: BAY 41-2272, supplier, activators, soluble, guanylyl, guanylate, cyclases, sGC, BAY41-2272

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

Sign-up for New Product E-alerts

Enter your email address below to sign up to receive our email updates:

divider line

Tocris Events

Win a Kindle

event

5th Conference on Advances in Molecular Mechanisms Underlying Neurological Disorders

June 23 - 26, 2013

Bath, UK