Cat. No. 4429
Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,
Biological ActivitySelective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bu et al (2001) Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 44 (12) 2004. PMID: 11384245.
Volynets et al (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 54 (8) 2680. PMID: 21449566.
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Keywords: NQDI 1, supplier, NQDI1, Apoptosis, signal-regulating, kinase, ASK1, inhibitors, MAP3K5