NQDI 1

Cat. No. 4429

NQDI 1 C19H13NO4 [175026-96-7]

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Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester

Biological Activity

Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).

Technical Data

M.Wt:
319.31
Formula:
C19H13NO4
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
175026-96-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bu et al (2001) Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 44 (12) 2004. PMID: 11384245.

Volynets et al (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 54 (8) 2680. PMID: 21449566.

If you know of a relevant citation for this product please let us know.

Keywords: NQDI 1, supplier, NQDI1, Apoptosis, signal-regulating, kinase, ASK1, inhibitors, MAP3K5

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