R&D Systems Inc. Tocris Bioscience Boston Biochem

NQDI 1

Cat. No. 4429

NQDI 1 C19H13NO4 [175026-96-7]

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Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,­2,3-de]quinoline-1-carboxylic acid ethyl ester

Biological Activity

Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).

Technical Data

M.Wt:
319.31
Formula:
C19H13NO4
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
175026-96-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bu et al (2001) Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 44 (12) 2004. PMID: 11384245.

Volynets et al (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 54 (8) 2680. PMID: 21449566.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Apoptosis Kinases MAPK Other Apoptosis
Other Kinases Other MAPK Other MAPK

Keywords: NQDI 1, supplier, Apoptosis, signal-regulating, kinase, ASK1, inhibitors, MAP3K5

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