Cat. No. 4426
Chemical Name: 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
Biological ActivityMajor tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Also displays antioxidant and anti-inflammatory properties.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Liu et al (2006) Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. J.Biomed.Sci. 13 813. PMID: 16955348.
Wang et al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11. PMID: 16955220.
Jin et al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15. PMID: 17979138.
Lee et al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527.
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Keywords: Tanshinone IIA, supplier, TanshinoneIIA, tanshinone, cytotoxic, inhibitors, inhibits, nf-kappab, nf-kb, nf-κb, ap-1, dna, binding
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