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Tanshinone IIA

Cat. No. 4426

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Chemical Name: 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione

Biological Activity

Major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Also displays antioxidant and anti-inflammatory properties.

Technical Data

M.Wt:

294.34

Formula:

C₁₉H₁₈O₃

Solubility:

Soluble to 5 mM in DMSO with gentle warming

Purity:

>98 %

Storage:

Store at RT

CAS No:

568-72-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Liu et al (2006) Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. J.Biomed.Sci. 13 813. PMID: 16955348.

Wang et al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11. PMID: 16955220.

Jin et al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15. PMID: 17979138.

Lee et al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527.

If you know of a relevant citation for this product please let us know.

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Keywords: Tanshinone IIA, supplier, TanshinoneIIA, tanshinone, cytotoxic, inhibitors, inhibits, nf-kappab, nf-kb, nf-κb, ap-1, dna, binding

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