ADX 10059 hydrochloride
Cat. No. 4416
Chemical Name: 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
Biological ActivityReported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Keywood et al (2009) A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 58 1192. PMID: 19460767.
Marin and Goadsby (2010) Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 19 555. PMID: 20218930.
Weiss et al (2011) 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 21 4891. PMID: 21757343.
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Keywords: ADX 10059 hydrochloride, supplier, metabotropics, glutamate, receptor, 5, mglur5, mglu5, NAMs, negative, allosteric, modulators, ADX10059
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October 15, 2013