R&D Systems Inc. Tocris Bioscience Boston Biochem

ADX 10059 hydrochloride

Cat. No. 4416

ADX 10059 hydrochloride C15H13FN2.HCl [757949-98-7]

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Chemical Name: 2-[(3-Fluorophenyl)ethynyl]-4,6-dim­ethyl-3-pyridinamine hydrochloride

Biological Activity

Reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).

Technical Data

M.Wt:
276.74
Formula:
C15H13FN2.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
757949-98-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Keywood et al (2009) A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 58 1192. PMID: 19460767.

Marin and Goadsby (2010) Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 19 555. PMID: 20218930.

Weiss et al (2011) 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 21 4891. PMID: 21757343.

If you know of a relevant citation for this product please let us know.

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Keywords: ADX 10059 hydrochloride, supplier, metabotropics, glutamate, receptor, 5, mglur5, mglu5, NAMs, negative, allosteric, modulators, ADX10059

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