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DMOG

Cat. No. 4408

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Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester

Biological Activity

Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions.

Technical Data

M.Wt:

175.14

Formula:

C₆H₉NO₅

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Storage:

Store at -20°C

CAS No:

89464-63-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Jaakkola et al (2001) Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O₂-regulated prolyl hydroxylation. Science 292 468. PMID: 11292861.

Lomb et al (2009) Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic neurons. Mol.Pharmacol. 75 1198. PMID: 19204094.

Ayrapetov et al (2011) Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 6 e26064. PMID: 22016813.

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