R&D Systems Inc. Tocris Bioscience Boston Biochem

NVP BHG 712

Cat. No. 4405

NVP BHG 712 C26H20F3N7O.CF3CO2H [940310-85-0]

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Chemical Name: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide trifluoroacetate

Biological Activity

Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.

Technical Data

M.Wt:
617.5
Formula:
C26H20F3N7O.CF3CO2H
Solubility:
Soluble to 40 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
940310-85-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Martiny-Baron et al (2010) The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 13 259. PMID: 20803239.

Wnuk et al (2012) Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 81 1212. PMID: 22398409.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: NVP BHG 712, supplier, NVPBHG712, EphB4, kinase, inhibitors, inhibits, ephrinB2, EphB2, ephrin, VEGF, angiogenesis, antiangiogenics

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