R&D Systems Inc. Tocris Bioscience Boston Biochem

Thiamet G

Cat. No. 4390

Thiamet G C9H16N2O4S [1009816-48-1]

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Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

Biological Activity

Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Orally bioavailable and blood brain barrier permeable.

Technical Data

M.Wt:
248.3
Formula:
C9H16N2O4S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at -20°C
CAS No:
1009816-48-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483. PMID: 18587388.

If you know of a relevant citation for this product please let us know.

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Keywords: Thiamet G, supplier, glycosidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, O-GlcNAcase, ThiametG

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