Cat. No. 4390
Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3
Biological ActivityPotent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Orally bioavailable and blood brain barrier permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483. PMID: 18587388.
If you know of a relevant citation for this product please let us know.
Keywords: Thiamet G, supplier, glycosidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, O-GlcNAcase, ThiametG
Find multiple products by catalog number
New Products in this Area
Ces3 and Ces1f inhibitor968
Allosteric inhibitor of glutaminaseARN 272
FAAH-like anandamide transporter (FLAT) inhibitorML 349
Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
September 5 - 8, 2015