Calhex 231 hydrochloride
Cat. No. 4387
Chemical Name: 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-n
Biological ActivityNegative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3H]inositol phosphate levels elicited by wild-type hCasR activation (IC50= 0.39 μM in transiently transfected HEK293 cells).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Petrel et al (2003) Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca2+-sensing receptor. J.Biol.Chem. 278 49487. PMID: 14506236.
Kessler et al (2006) N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J.Med.Chem. 49 5119. PMID: 16913701.
Weston et al (2008) The expression and function of Ca2+-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes. Br.J.Pharmacol. 154 652. PMID: 18414396.
If you know of a relevant citation for this product please let us know.
Keywords: Calhex 231 hydrochloride, supplier, Calhex231, calcilytics, hcasr, calcium-sensing, receptors, negative, allosteric, modulators, nams
Find multiple products by catalog number
New Products in this Area
P2Y12 inhibitorRactopamine hydrochloride
Trace amine 1 (TA1) receptor agonistTG 4-155
High affinity and selective EP2 receptor antagonistSAG
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathwayDC 260126
FFA1 (GPR40) antagonistAR-C 118925XX
Selective, competitive P2Y2 receptor antagonistEPPTB
Trace amine 1 (TA1) receptor antagonist/inverse agonistNIBR 189
Potent and selective EBI2 (GPR183) receptor antagonistONO AE3 208
High affinity and selective EP4 antagonist
May 19 - 22, 2015