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Donepezil hydrochlorideCat. No. 4385 |
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Alternative Name: E 2020 Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride |
Biological Activity
Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.Certificate of Analysis / Safety Data Sheet
References
Sugimoto et al (1995) Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 38 4821. PMID: 7490731.
Kryger et al (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 7 297. PMID: 10368299.
Sugimoto et al (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 7 303. PMID: 10637367.
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Keywords: Donepezil hydrochloride, supplier, acetylcholinesterase, ache, selective, potent, inhibitors, E2020
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