WAY 100635 maleate
Cat. No. 4380
Chemical Name: N-[2-[4-(2-Methoxyphenyl)-1-piperaz
Biological ActivityPotent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Zhuang et al (1994) Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand. J.Med.Chem. 37 1406. PMID: 8182697.
Forster et al (1995) A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur.J.Pharmacol. 281 81. PMID: 8566121.
Mensonides-Harsema et al (2000) Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635. J.Med.Chem. 43 432. PMID: 10669570.
Chemel et al (2006) WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl). 188 244. PMID: 16915381.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: WAY 100635 maleate, supplier, WAY100635, 5-ht1a, serotonin, serotonergics, selective, antagonists, dopamine, D4, antagonists, dopaminergics, 5-HT1A Receptor Antagonists
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.