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VU 0364439Cat. No. 4371 |
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Chemical Name: N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide |
Biological Activity
Positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).Certificate of Analysis / Safety Data Sheet
References
Engers et al (2010) Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorg.Med.Chem.Lett. 20 5175. PMID: 20667732.
Robichaud et al (2011) Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. ACS Chem.Neurosci. 2 433.
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Keywords: VU 0364439, supplier, VU0364439, potent, mGlu4, mGluR4, postive, allosteric, modulators, PAMs, metabotropic, glutamate, 4, receptors
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