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TC-SP 14

Cat. No. 4363

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Chemical Name: 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid

Biological Activity

Potent and selective S1P₁ agonist (EC₅₀ values are 0.042 and 3.47 μM for human S1P₁ and S1P₃ respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Technical Data

M.Wt:

450.5

Formula:

C₂₅H₂₀F₂N₂O₂S

Solubility:

Soluble to 50 mM in DMSO with gentle warming

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

1257093-40-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Lanman et al (2011) Discovery of a potent, S1P₃-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P₁). ACS Med.Chem.Lett. 2 102.

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Sphingosine-1-Phosphate Receptors

Keywords: TC-SP 14, supplier, TCSP14, Potent, sphingosine, 1, phosphate, 1, receptor, S1P1, agonist, delayed, type, hypersensitivity, immune, response, orally, bioavailable

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