TC-F 2

Cat. No. 4355

TC-F 2 C26H25N5O2 [1304778-15-1]

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Chemical Name: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Biological Activity

Potent, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 values are 28 and 100 nM for human and rat FAAH respectively). Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC50 > 20 μM for CB1, CB2 and TRPV1). Active in vivo.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Gustin et al (2011) Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett. 21 2492. PMID: 21392988.

Min et al (2011) Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc.Natl.Acad.Sci.U.S.A. 108 7379. PMID: 21502526.

If you know of a relevant citation for this product please let us know.

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Keywords: TC-F 2, supplier, TCF2, TC-F2, fatty, acid, amide, hydrolase, FAAH, inhibits, inhibitors, reversible, noncovalent, potent, in, vivo, selective, FAAH Inhibitors

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