Cat. No. 4354
Chemical Name: 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine
Biological ActivityPotent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Correa et al (2011) Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem.Biol. 18 825. PMID: 21802003.
Khan et al (2011) Identification of inhibitors of NOD1-induced nuclear factor-κB activation. ACS Med.Chem.Lett. 2 780. PMID: 22003428.
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Keywords: ML 130, supplier, ML130, nf-kb, nf-kappab, nf-μb, inhibitors, inhibits, NOD1, nucleotide-binding, oligomerization, domain, 1, selective, potent
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