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TC-G 24

Cat. No. 4353

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Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine

Biological Activity

Potent GSK-3β inhibitor (IC₅₀ = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data

M.Wt:

330.73

Formula:

C₁₅H₁₁ClN₄O₃

Solubility:

Soluble to 10 mM in DMSO with gentle warming

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

1257256-44-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534. PMID: 21082766.

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Keywords: TC-G 24, supplier, TC-G24, glycogen, synthase, kinase, 3, beta, b, β, gsk3beta, gsk3β, potent, inhibits, inhibitors, selective, brain, penetrant, liver, hinge, region, binder

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