Cat. No. 4347
Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester
Biological ActivityPositive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 98 13402. PMID: 11606768.
Hempstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Ro 67-4853, supplier, Ro67-4853, PAM, positive, allosteric, modulator, modulators, metabotropic, glutamate, receptor, 1, enhancer, mGlu1, receptors
Find multiple products by catalog number
New Products in this Area
Selective negative allosteric modulator of group II mGlu receptorsVU 0285683
Negative allosteric modulator at mGlu5
Win a Kindle
June 3 - 5, 2013
Booth Number: C54