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Ro 67-4853

Cat. No. 4347

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Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester

Biological Activity

Positive allosteric modulator of mGlu group I receptors (pEC₅₀ value is 7.16 for the rat mGlu_1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu₁ and rat mGlu₅. Enhances the effects of (S)-DHPG in CA3 neurons (EC₅₀ = 95 nM).

Technical Data

M.Wt:

325.36

Formula:

C₁₉H₁₉NO₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

302841-89-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 98 13402. PMID: 11606768.

Hempstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124.

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