Cat. No. 4344
Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophe
Biological ActivityInhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Handeli and Simon (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 7 521. PMID: 18347139.
If you know of a relevant citation for this product please let us know.
Keywords: FH 535, supplier, FH535, wnt, beta-catenin, inhibitor, inhibits, bcat, bcatenin, TCFPPARg, PPARd, PPARgamma, PPARdelta, peroxisome, proliferator-activated, receptor, antagonist
Find multiple products by catalog number
One Day Symposium
March 17, 2015