Cat. No. 4344
Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophe
Biological ActivityInhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Handeli and Simon (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 7 521. PMID: 18347139.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: FH 535, supplier, FH535, wnt, beta-catenin, inhibitor, inhibits, bcat, bcatenin, TCFPPARg, PPARd, PPARgamma, PPARdelta, peroxisome, proliferator-activated, receptor, antagonist, Tocris Bioscience, β-catenin
Find multiple products by catalog number
New Products in this Area
Wnt pathway inhibitor
March 14 - 16, 2016
New Orleans, LA, USA