Cat. No. 4343
Chemical Name: 2-Cyclohexyl-6-methoxy-N-[1-(1-meth
Biological ActivitySelective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Cell permeable.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0638 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Liu et al (2011) Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J.Med.Chem. 54 6139. PMID: 21780790.
Vedadi et al (2011) A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol. 7 566. PMID: 21743462.
If you know of a relevant citation for this product please let us know.
Keywords: UNC 0638, supplier, G9a, GLP, histone, lysine, methyltransferases, HMTs, HMTases, epigenetics, histone, modifications, H3K9, H3K9me2, potent, selective, inhibits, inhibitors, UNC0638
Find multiple products by catalog number
New Products in this Area
N-acetyltransferase 10 (NAT10) inhibitorEPZ 004777
Highly potent DOT1L inhibitorOICR 9429
High affinity and selective WDR5 antagonistMM 102
WDR5/MLL interaction inhibitorUNC 2327
Allosteric inhibitor of PRMT3GSK 2194069
Potent human fatty acid synthase (hFAS) inhibitorFuramidine dihydrochloride
Selective PRMT1 inhibitorXY1
Negative control of SGC 707 (Cat. No. 5367)SGC 707
Potent and selective allosteric inhibitor of PRMT3
Tocris Product News
SGC Epigenetic Probes
Introducing our new epigenetics probes provided in collaboration with the Structural Genomics Consortium (SGC).