UNC 0638

Cat. No. 4343

UNC 0638 C30H47N5O2 [1255517-77-1]

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Chemical Name: 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Biological Activity

Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Cell permeable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0638 probe summary on the SGC website.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol and to 100 mM in 1eq. HCl
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Liu et al (2011) Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J.Med.Chem. 54 6139. PMID: 21780790.

Vedadi et al (2011) A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol. 7 566. PMID: 21743462.

If you know of a relevant citation for this product please let us know.

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Keywords: UNC 0638, supplier, G9a, GLP, histone, lysine, methyltransferases, HMTs, HMTases, epigenetics, histone, modifications, H3K9, H3K9me2, potent, selective, inhibits, inhibitors, UNC0638, Lysine Methyltransferase Inhibitors

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