R&D Systems Inc. Tocris Bioscience Boston Biochem

JW 480

Cat. No. 4327

JW 480 C22H23NO2 [1354359-53-7]

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Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate

Biological Activity

Potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50 = 20 nM in mouse brain). Impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo. Reduces monoalkylglycerol ether (MAGE) levels.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data

M.Wt:
333.42
Formula:
C22H23NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at -20°C
CAS No:
1354359-53-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Chang et al (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 18 476. PMID: 21513884.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: JW 480, supplier, KIAA1363, inhibitor, inhibits, KIAA, 1363, prostate, cancer, AADACL1, MAGE, monoalkylglycerol, ether, JW480

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