Cat. No. 4327
Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-y
Biological ActivityPotent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50 = 20 nM in mouse brain). Impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo. Reduces monoalkylglycerol ether (MAGE) levels.
Licensing InformationSold under license from The Scripps Research Institute.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chang et al (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 18 476. PMID: 21513884.
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Keywords: JW 480, supplier, KIAA1363, inhibitor, inhibits, KIAA, 1363, prostate, cancer, AADACL1, MAGE, monoalkylglycerol, ether, JW480, Other Hydrolase Inhibitors