JW 480

Cat. No. 4327

JW 480 C22H23NO2 [1354359-53-7]

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Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate

Biological Activity

Potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50 = 20 nM in mouse brain). Impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo. Reduces monoalkylglycerol ether (MAGE) levels.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Chang et al (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 18 476. PMID: 21513884.

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Keywords: JW 480, supplier, KIAA1363, inhibitor, inhibits, KIAA, 1363, prostate, cancer, AADACL1, MAGE, monoalkylglycerol, ether, JW480, Other Hydrolase Inhibitors

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