Cat. No. 4305
Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Biological ActivitySelective KV7.2/KV7.3 (KCNQ2/3) potassium channel opener (EC50 = 0.69 μM). 20-fold selective for KV7.2/KV7.3 over KV7.3/KV7.5 with no measurable activity over a panel of cardiac ion channels (IC50 >30 μM for KV11.1 (hERG), NaV1.5, L-type channels and KV7.1). Orally active in several animal models of epilepsy.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481.
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Keywords: ICA 069673, supplier, ICA069673, KCNQ2, KCNQ3, kv7.2, kv7.3, channel, opener, potassium, K+, voltage, gated, potassium, channel, openers, Kv
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October 15, 2013