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ICA 069673

Cat. No. 4305

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Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Biological Activity

Selective K_V7.2/K_V7.3 (KCNQ2/3) potassium channel opener (EC₅₀ = 0.69 μM). 20-fold selective for K_V7.2/K_V7.3 over K_V7.3/K_V7.5 with no measurable activity over a panel of cardiac ion channels (IC₅₀ >30 μM for K_V11.1 (hERG), Na_V1.5, L-type channels and K_V7.1). Orally active in several animal models of epilepsy.

Technical Data

M.Wt:

269.63

Formula:

C₁₁H₆ClF₂N₃O

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

582323-16-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481.

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