Home » Pharmacology » Enzymes » Proteases » Angiotensin-Converting Enzyme » Perindopril erbumine

Perindopril erbumine

Cat. No. 4302

Price and Availability

For Perindopril erbumine pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice.

Technical Data

M.Wt:

441.6

Formula:

C₁₉H₃₂N₂O₅.C₄H₁₁N

Solubility:

Soluble to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

107133-36-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Takai et al (2004) Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 27 213. PMID: 15080380.

Ceconi et al (2007) Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur.J.Pharmacol. 577 1. PMID: 17716647.

Dong et al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 25 2911. PMID: 21593435.

If you know of a relevant citation for this product please let us know.