Cat. No. 4302
Chemical Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Et
Biological ActivityAngiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Takai et al (2004) Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 27 213. PMID: 15080380.
Ceconi et al (2007) Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur.J.Pharmacol. 577 1. PMID: 17716647.
Dong et al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 25 2911. PMID: 21593435.
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Keywords: Perindopril erbumine, supplier, inhibits, angiotensin-converting, enzyme, ACE, inhibitor
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