R&D Systems Inc. Tocris Bioscience Boston Biochem

Perindopril erbumine

Cat. No. 4302

Perindopril erbumine C19H32N2O5.C4H11N [107133-36-8]

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Chemical Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice.

Technical Data

M.Wt:
441.6
Formula:
C19H32N2O5.C4H11N
Solubility:
Soluble to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
107133-36-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Takai et al (2004) Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 27 213. PMID: 15080380.

Ceconi et al (2007) Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur.J.Pharmacol. 577 1. PMID: 17716647.

Dong et al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 25 2911. PMID: 21593435.

If you know of a relevant citation for this product please let us know.

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Keywords: Perindopril erbumine, supplier, inhibits, angiotensin-converting, enzyme, ACE, inhibitor

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