Cat. No. 4301
Chemical Name: (4Z)-2-[(E)-2-Phenylethenyl)-4-(3-p
Biological ActivityPotent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323. PMID: 19877644.
If you know of a relevant citation for this product please let us know.
Keywords: TC-DAPK 6, supplier, TC-DAPK6, death-associated, protein, kinase, dapk1, selective, potent, inhibitors, inhibits, 315694-89-4
Find multiple products by catalog number
New Products in this Area
CaM kinase II inhibitor; water soluble version of KN-93 (Cat. No. 1278).Bryostatin 3
Potent protein kinase C activatorGKA 50
Glucokinase activatorMRT 67307 dihydrochloride
Salt inducible kinase (SIK) inhibitorLDN 209929 dihydrochloride
Potent and selective haspin kinase inhibitorRKI 1447 dihydrochloride
Potent and selective ROCK inhibitor; antitumorLIMKi 3
Potent LIM kinase inhibitor; antitumorFRAX 486
Potent p21-activated kinase (PAK) inhibitor; brain penetrant and orally bioavailableBIX 02189
Selective MEK5 and ERK5 inhibitorTC Mps1 12
Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor; orally activeGSK 2606414
Potent and selective PERK inhibitor; orally bioavailableAZ 20
Potent and selective ATR kinase inhibitor; antitumorAZD 7762 hydrochloride
Potent and selective ATP-competitive inhibitor of Chk1 and Chk2PHT 427
Dual Akt and PDK1 inhibitor; antitumorML 786 dihydrochloride
Potent Raf kinase inhibitor; orally bioavailableSenexin A
Cyclin-dependent kinase 8 (cdk8) inhibitorXL 388
Potent and selective mTOR inhibitor; antitumor
December 6 - 10, 2014
Booth Number: 515