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TC-DAPK 6

Cat. No. 4301

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Chemical Name: (4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone

Biological Activity

Potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC₅₀ values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC₅₀ > 10 μM).

Technical Data

M.Wt:

276.29

Formula:

C₁₇H₁₂N₂O₂

Solubility:

Soluble to 50 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

315694-89-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323. PMID: 19877644.

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