R&D Systems Inc. Tocris Bioscience Boston Biochem

TC-DAPK 6

Cat. No. 4301

TC-DAPK 6 C17H12N2O2 [315694-89-4]

Price and Availability

For TC-DAPK 6 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone

Biological Activity

Potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).

Technical Data

M.Wt:
276.29
Formula:
C17H12N2O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
315694-89-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323. PMID: 19877644.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: TC-DAPK 6, supplier, TC-DAPK6, death-associated, protein, kinase, dapk1, selective, potent, inhibitors, inhibits

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

Sign-up for New Product E-alerts

Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

RSVA 405

AMPK activator

Atiprimod dihydrochloride

JAK2 Inhibitor

AIM 100

Potent and selective Ack1 inhibitor

ML 120B dihydrochloride

Novel IKK2-selective inhibitor

ML 202

Pyruvate kinase M2 activator

GNF 5

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

TC-S 7005

Potent and selective PLK2 inhibitor

SRPIN340

Selective SRPK1 inhibitor

TC-S 7003

Potent Lck inhibitor

ML 281

STK33 inhibitor

CRT 0066101

Potent protein kinase D (PKD) inhibitor

Harmine

Potent and selective Dyrk1A inhibitor

AZ 628

Potent Raf kinase inhibitor

CHIR 99021 trihydrochloride

Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor

YZ9

PFKFB3 inhibitor; inhibits cell growth

KU 0060648

Dual DNA-PK and PI 3-K inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.