Cat. No. 4301
Chemical Name: (4Z)-2-[(E)-2-Phenylethenyl)-4-(3-p
Biological ActivityPotent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323. PMID: 19877644.
If you know of a relevant citation for this product please let us know.
Keywords: TC-DAPK 6, supplier, TC-DAPK6, death-associated, protein, kinase, dapk1, selective, potent, inhibitors, inhibits, 315694-89-4
Find multiple products by catalog number
New Products in this Area
Potent DYRK1B inhibitorETP 45658
Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTORPFK 15
Selective PFKFB3 inhibitorPD 0332991 isethionate
Potent, selective Cdk4/6 inhibitor; brain penetrantXL 413 hydrochloride
Potent and selective Cdc7 inhibitorC16
PKR inhibitorRp-8-pCPT-cGMPS sodium
PKG inhibitorTC-S 7004
Potent and selective DYRK1A/B inhibitorTAK 960 hydrochloride
Potent and selective PLK1 inhibitorA12B4C3
Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitorBMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatoryWH-4-023
Potent and selective Lck and Src inhibitor; also inhibits SIKTC-S 7006
Potent and selective Tpl2 (Cot; MAP3K8) inhibitorOXA 06 dihydrochloride
Potent ROCK inhibitorPCI 29732
Potent BTK inhibitorMps1-IN-1 dihydrochloride
Selective monopolar spindle 1 (Mps1) kinase inhibitorCKI 7 dihydrochloride
CK1 inhibitorT 5601640
Selective LIMK2 inhibitor; antitumor3PO
PFKFB3 inhibitor; antiangiogenic
September 5 - 8, 2015