R&D Systems Inc. Tocris Bioscience Boston Biochem

VU 0357017 hydrochloride

Cat. No. 4295

VU 0357017 hydrochloride C18H27N3O3.HCl [1135242-13-5]

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Chemical Name: 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride

Biological Activity

Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

Technical Data

M.Wt:
369.89
Formula:
C18H27N3O3.HCl
Solubility:
Soluble to 25 mM in water and to 5 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1135242-13-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg.Med.Chem.Lett. 20 1972. PMID: 20156687.

Lebois et al (2010) Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system. ACS Chem.Neurosci. 1 104.

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Keywords: VU 0357017 hydrochloride, supplier, VU0357017, hydrochloride, muscarinics, acetylcholine, machrs, positive, allosteric, modulators, pams, m1, selective

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