Cat. No. 4291
Chemical Name: 6-Bromo-7-[4-[(5-methyl-3-isoxazoly
Biological ActivityPotent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 μM at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a range of human tumor cell lines. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bavetsias et al (2010) Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J.Med.Chem. 53 5213. PMID: 20565112.
Faisal et al (2011) The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol.Cancer Ther. 10 2115. PMID: 21885865.
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Keywords: CCT 137690, supplier, CCT137690, aurora, kinases, pan-aurora, inhibitors, antiproliferative, Tocris Bioscience, Aurora Kinase Inhibitors
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March 14 - 16, 2016
New Orleans, LA, USA