R&D Systems Inc. Tocris Bioscience Boston Biochem

CCT 137690

Cat. No. 4291

CCT 137690 C26H31BrN8O [1095382-05-0]

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Chemical Name: 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine

Biological Activity

Potent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 μM at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a range of human tumor cell lines. Orally bioavailable.

Technical Data

M.Wt:
551.48
Formula:
C26H31BrN8O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1095382-05-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Bavetsias et al (2010) Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J.Med.Chem. 53 5213. PMID: 20565112.

Faisal et al (2011) The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol.Cancer Ther. 10 2115. PMID: 21885865.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: CCT 137690, supplier, CCT137690, aurora, kinases, pan-aurora, inhibitors, antiproliferative

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