Poly(I:C)

Cat. No. 4287

Poly(I:C) (C10H13N4O8P)x.(C9H14N3O8P)x [24939-03-5]

Price and Availability

For Poly(I:C) pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: Polyinosinic-polycytidylic acid sodium salt

Biological Activity

Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.

Technical Data

Formula:
(C10H13N4O8P)x.(C9H14N3O8P)x
Solubility:
Soluble to 3 mg/ml in water
Storage:
Store at -20°C
CAS No:
24939-03-5

Resources

Other Information

  • To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616. PMID: 12960048.

Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767. PMID: 15096480.

West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476. PMID: 21525932.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Poly(I:C), supplier, Poly(I:C), immunostimulant, toll-like, receptor, TLR, TLR3, agonist, inosinic, acid, cytidylic, acid, double-stranded, RNA, dsRNA, synthetic, Tocris Bioscience, Toll-like Receptor Agonists

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Toll-like Receptor Pathway

Toll-like Receptor Signaling Pathway

Toll-like receptors are important in the inflammatory and adaptive and innate immune responses against threatening microbes. View pathway or download PDF today.

divider line

New Products in this Area

6877002

CD40-TRAF6 interaction inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.