Poly(I:C)

Cat. No. 4287

Poly(I:C) (C10H13N4O8P)x.(C9H14N3O8P)x [24939-03-5]

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Chemical Name: Polyinosinic-polycytidylic acid sodium salt

Biological Activity

Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.

Technical Data

Formula:
(C10H13N4O8P)x.(C9H14N3O8P)x
Solubility:
Soluble in water
Storage:
Store at -20°C
CAS No:
24939-03-5

Resources

Other Information

  • To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616. PMID: 12960048.

Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767. PMID: 15096480.

West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476. PMID: 21525932.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Poly(I:C), supplier, Poly(I:C), immunostimulant, toll-like, receptor, TLR, TLR3, agonist, inosinic, acid, cytidylic, acid, double-stranded, RNA, dsRNA, synthetic

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