R&D Systems Inc. Tocris Bioscience Boston Biochem

Poly(I:C)

Cat. No. 4287

Poly(I:C) (C10H13N4O8P)x.(C9H14N3O8P)x [24939-03-5]

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Chemical Name: Polyinosinic-polycytidylic acid sodium salt

Biological Activity

Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.

Technical Data

Formula:
(C10H13N4O8P)x.(C9H14N3O8P)x
Solubility:
Soluble in water
Storage:
Store at -20°C
CAS No:
24939-03-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

  • To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616. PMID: 12960048.

Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767. PMID: 15096480.

West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476. PMID: 21525932.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Poly(I:C), supplier, Poly(I:C), immunostimulant, toll-like, receptor, TLR, TLR3, agonist, inosinic, acid, cytidylic, acid, double-stranded, RNA, dsRNA, synthetic

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