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UA 62784Cat. No. 4286 |
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Chemical Name: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one |
Biological Activity
Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.Certificate of Analysis / Safety Data Sheet
References
Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 18 679. PMID: 21700202.
Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631. PMID: 21609844.
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Keywords: UA 62784, supplier, UA62784, cytotoxic, antiproliferatives, microtubules, inhibitors, inhibits, polymerization, polymerisation
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