Cat. No. 4276
Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphen
Biological ActivityPotent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Harris et al (2003) Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 4241. PMID: 14500559.
Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021. PMID: 15456246.
Cvoro et al (2008) Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 180 630. PMID: 18097065.
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Keywords: ERB 041, supplier, pfizer, ERB041, potent, erb, erbeta, erγ, estrogen, receptors, agonists, selective
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