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ERB 041

Cat. No. 4276

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Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol

Biological Activity

Potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC₅₀ values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:

271.24

Formula:

C₁₅H₁₀FNO₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

524684-52-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Harris et al (2003) Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 4241. PMID: 14500559.

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021. PMID: 15456246.

Cvoro et al (2008) Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 180 630. PMID: 18097065.

If you know of a relevant citation for this product please let us know.

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Keywords: ERB 041, supplier, pfizer, ERB041, potent, erb, erbeta, erγ, estrogen, receptors, agonists, selective

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