Cat. No. 4273
Chemical Name: 5,11-Dihydro-2-[[2-methoxy-4-[[4-(4
Biological ActivityPotent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2.
Licensing InformationSold under license from the Dana-Farber Cancer Institute.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Deng et al (2011) Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat.Chem.Biol. 7 203. PMID: 21378983.
Zhao et al (2015) LRRK2 Dephosphorylation increases its ubiquitination. Biochem.J.. PMID: 25939886.
If you know of a relevant citation for this product please let us know.
Keywords: LRRK2-IN-1, supplier, parkinsons, disease, lrrk2, leucine-rich, repeat, kinase, 2, dardarin, parkinson's
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