R&D Systems Inc. Tocris Bioscience Boston Biochem

LRRK2-IN-1

Cat. No. 4273

LRRK2-IN-1 C31H38N8O3 [1234480-84-2]

Price and Availability

For LRRK2-IN-1 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Biological Activity

Potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively).

Licensing Information

Sold under license from the Dana-Farber Cancer Institute.

Technical Data

M.Wt:
570.09
Formula:
C31H38N8O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1234480-84-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Deng et al (2011) Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat.Chem.Biol. 7 203. PMID: 21378983.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: LRRK2-IN-1, supplier, parkinsons, disease, lrrk2, leucine-rich, repeat, kinase, 2, dardarin, parkinson's

Quick Order

Find multiple products by catalog number

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Neurobiology of Parkinson's Disease

Written by A. Schapira

Parkinson's Poster

'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

RSVA 405

AMPK activator

Atiprimod dihydrochloride

JAK2 Inhibitor

AIM 100

Potent and selective Ack1 inhibitor

ML 120B dihydrochloride

Novel IKK2-selective inhibitor

ML 202

Pyruvate kinase M2 activator

GNF 5

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

TC-S 7005

Potent and selective PLK2 inhibitor

SRPIN340

Selective SRPK1 inhibitor

TC-S 7003

Potent Lck inhibitor

ML 281

STK33 inhibitor

CRT 0066101

Potent protein kinase D (PKD) inhibitor

Harmine

Potent and selective Dyrk1A inhibitor

AZ 628

Potent Raf kinase inhibitor

CHIR 99021 trihydrochloride

Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor

YZ9

PFKFB3 inhibitor; inhibits cell growth

KU 0060648

Dual DNA-PK and PI 3-K inhibitor

KB SRC 4

Potent and selective c-Src inhibitor

Sign-up for new product e-alerts
divider line

Tocris Events

ICRS 2014

International Cannabinoid Research Society Symposium 2014

June 28 - July 3, 2014

Baveno, Italy