R&D Systems Inc. Tocris Bioscience Boston Biochem

ML 141

Cat. No. 4266

ML 141 C22H21N3O3S [71203-35-5]

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Alternative Name: CID 2950007

Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide

Biological Activity

Allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Technical Data

M.Wt:
407.49
Formula:
C22H21N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
71203-35-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Surviladze et al (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program NBK5196. PMID: 21433396.

Hong et al (2013) Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. Epub. PMID: 23382385.

If you know of a relevant citation for this product please let us know.

Keywords: ML 141, supplier, ML141, CID2950007, inhibits, cdc42, Rho, GTPase, inhibitor, inhibitors

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