R&D Systems Inc. Tocris Bioscience Boston Biochem

TMPyP4 tosylate

Cat. No. 4253

TMPyP4 tosylate C72H66N8O12S4 [36951-72-1]

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Chemical Name: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)

Biological Activity

Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

Technical Data

M.Wt:
1363.6
Formula:
C72H66N8O12S4
Solubility:
Soluble to 50 mM in water
Purity:
>95 %
Storage:
Store at +4°C
CAS No:
36951-72-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wheelhouse et al (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc. 120 3261.

Rha et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 6 987. PMID: 10741725.

Shi et al (2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem. 474 4509.

Shammas et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2 825. PMID: 14555701.

If you know of a relevant citation for this product please let us know.

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Keywords: TMPyP4 tosylate, supplier, TMPyP4, telomerase, inhibitors, g, tetrads, quadruplex, DNA, telomeres

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