TMPyP4 tosylate

Cat. No. 4253

TMPyP4 tosylate C72H66N8O12S4 [36951-72-1]

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Chemical Name: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)

Biological Activity

Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

Technical Data

Soluble to 50 mM in water
>95 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Wheelhouse et al (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc. 120 3261.

Rha et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 6 987. PMID: 10741725.

Shi et al (2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem. 474 4509.

Shammas et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2 825. PMID: 14555701.

If you know of a relevant citation for this product please let us know.

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Keywords: TMPyP4 tosylate, supplier, TMPyP4, telomerase, inhibitors, g, tetrads, quadruplex, DNA, telomeres, Telomerase Inhibitors

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